Identification of small molecule compounds that inhibit the HIF-1 signaling pathway
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چکیده
منابع مشابه
Identification of small molecule compounds that selectively inhibit varicella-zoster virus replication.
A series of nonnucleoside, N-alpha-methylbenzyl-N'-arylthiourea analogs were identified which demonstrated selective activity against varicella-zoster virus (VZV) but were inactive against other human herpesviruses, including herpes simplex virus. Representative compounds had potent activity against VZV early-passage clinical isolates and an acyclovir-resistant isolate. Resistant viruses genera...
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NOD1 is an intracellular pattern recognition receptor that recognizes diaminopimelic acid (DAP), a peptidoglycan component in gram negative bacteria. Upon ligand binding, NOD1 assembles with receptor-interacting protein (RIP)-2 kinase and initiates a signaling cascade leading to the production of pro-inflammatory cytokines. Increased NOD1 signaling has been associated with a variety of inflamma...
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ژورنال
عنوان ژورنال: Molecular Cancer
سال: 2009
ISSN: 1476-4598
DOI: 10.1186/1476-4598-8-117